Veterinary Clinical Research
CANINE OSTEOARTHRITIS STUDY
Accepted for publication in Canadian Veterinary Journal.
As pets age, quality of life and mobility can be impacted by pain of osteoarthritis and age-related muscle atrophy (sarcopenia). The purpose of this randomized, double-blinded, placebo controlled study was to evaluate the effects of Fortetropin®, a nonthermal-pasteurized, freeze-dried, fertilized egg yolk product, on mobility in senior dogs. Mobility scores were calculated using a standardized and validated client-based survey, the Liverpool Osteoarthritis in Dogs (LOAD) questionnaire. Results showed mild, but statistically significant, improvement of the mobility scores for the treatment group at both week 6 (p= 0.03) and week 12 (p= 0.006) compared to the baseline score. No statistical improvement was noted at any time point in the placebo group or between the treatment and placebo group.
TPLO SURGERY STUDY
A randomized, double-blind, placebo-controlled study was performed at Kansas State University to evaluate the impact of Fortetropin on muscle atrophy in 100 dogs after TPLO surgery (similar to ACL surgery in humans to repair torn ligament). The key findings of this clinical study were:
- Fortetropin® prevented the loss of muscle mass in the affected and unaffected limbs.
- Fortetropin-supplemented dogs had a more significant improvement in percentage of weight supported by the affected limb.
- Fortetropin prevented a rise in serum myostatin levels (myostatin is a protein that prevents muscle growth.)
White, Dana A., et al. “Fortetropin inhibits disuse muscle atrophy in dogs after tibial plateau leveling osteotomy.” PLOS ONE 15.4 (2020): e0231306.
SERUM MYOSTATIN IN DOGS
In a Randomized, Placebo-Controlled Cross-Over Study, Administration of 6 and 12 G Fortetropin® Does Not Reduce Serum Myostatin in Healthy Adult Dogs Over 72-Hours.
Objective: To evaluate the effect of a single administration of 6 and 12 g of Fortetropin compared to placebo on serum myostatin in healthy, adult dogs over a 72-h period.